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Hoyan Pharmaceutical (Wuhan) Co., Ltd.

20产品信息, 5最新消息, 78销售信息

2024 Top Grade Hormones CAS:171596-29-5 Tadalafil Powder Cialis Powder Whatsapp:+44 7746632140

2024 Top Grade Hormones CAS:171596-29-5 Tadalafil Powder Cialis Powder Whatsapp:+44 7746632140

2024/5/29 ~ 2024/12/31

说明

2024 Top Grade Hormones CAS:171596-29-5 Tadalafil Powder Cialis Powder Whatsapp:0086 15832901912

Cialis Supplier
Cialis Powder
Common Name:Tadalafil
Synonyms:Cialis
CAS Number 171596-29-5
Molecular Weight 389.404
Density 1.5±0.1 g/cm3
Boiling Point 679.1±55.0 °C at 760 mmHg
Molecular Formula C22H19N3O4
Melting Point 298-300ºC
Flash Point 364.5±31.5 °C
Symbol GHS02 GHS07
Purity 99%
Exact Mass 389.137543
PSA 74.87000
LogP 1.43
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.758
Storage condition Hygroscopic, -20?C Freezer, Under Inert Atmosphere

Use of Cialis
Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM.IC50 Value: 1.8±0.4nM [1]Target: PDE 5Tadalafil is marketed in pill form for treating erectile dysfunction(ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. Tadalafil can elevate the level of cGMP in the corpus cavernosum and effectively improve ED of various causes and degrees.in vitro: Biochemical potencies (affinities) of these compounds for PDE5 determined by IC(50), K(D) (isotherm), K(D) (dissociation rate), and K(D) ((1/2) EC(50)), respectively, were the following: sildenafil (3.7 +/- 1.4, 4.8 +/- 0.80, 3.7 +/- 0.29, and 11.7 +/- 0.70 nM), tadalafil (1.8 +/- 0.40, 2.4 +/- 0.60, 1.9 +/- 0.37, and 2.7 +/- 0.25 nM); and vardenafil (0.091 +/- 0.031, 0.38 +/- 0.07, 0.27 +/- 0.01, and 0.42 +/- 0.10 nM). Thus, absolute potency values were similar for each inhibitor, and relative potencies were vardenafil >> tadalafil > sildenafil [1]. 0.5 ml tadalafil solutions with different concentrations were added (0.2, 0.1, 0.05 and 0.025 μg ml-1, respectively) into semen samples. In both groups, samples treated with 0.2 μg ml-1 tadalafil had significant increase in sperm motility after 2 h incubation [2].in vivo: The Tadalafil-treated group showed enhanced erectile function (intracavernosal pressure/mean arterial pressure) at 0.3, 0.5, 1, 3, and 5 Hz compared with diabetic group values at the respective frequencies (P <.05) that approached control values [3]. oral administration of tadalafil (20 mg) or sildenafil (100 mg) was given. In both groups, computer-assisted semen analysis parameters showed no significant difference. After the administration of tadalafil (2 h) and sildenafil (1 h), there was no significant difference observed in premature acrosome reaction incidence rate [2].Clinical trial: Study the Safety and Effectiveness of Tadalafil in Men With Problems Getting or Maintaining an Erection When Taken Prior to Desiring an Erection. Phase 3.

Tadalafil Usage And Synthesis
Description Tadalafil (market name “Cialis” or “Adcirca”) was developed by American pharmaceutical company Lilly. It is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension.The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.
Chemical Properties White to Off-White Cyrstalline Powder
Uses Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.

If any need,Pls feel free to contact
Cayla Lei

Email: cayla.lei@whhoyan.com
sales7@whhoyan.com
What's app:+86 15832901912
Skype:+86 15832901912
Telagram:+86 19972823108
Threema:CZECN6M7

We guarantee 100% of your packages pass through the USA, UK, Australia, Canada ,Mexico, France, Germany, Spain, Belgium, Sweden, Poland, Russian.We have our own overseas warehouses in the United States, The United Kingdom, Germany, Mexico, Australia. Overseas warehouses can be shipped directly.

We have shipping agents in these countries, Our customs clearance company will clear your parcel without any customs issues, even 2000 kg at times. Door to door service.Ensure you 100% receive your goods. Let you have a nice experience of our strong ability to ship goods.

Hoyan Pharmaceutical (Wuhan) Co., Ltd.

Hoyan Pharmaceutical (Wuhan) Co., Ltd. is a collection of scientific research. Produce. Processing. Export as one of the professional chemical production enterprises. Mainly engaged in pharmaceutical intermediates and various industrial chemicals. Based on good quality and very competitive price, we have many years of professional experience, our products are widely used in different countries around the world.

Our company adopts the strategic idea of customer first, quality first, reputation first, strengthens reform with advanced technology, improves the management system with the correct concept, and increases investment to improve equipment.

Our company works hand in hand with enterprises all over the world to achieve a win-win situation. In the business cooperation with customers, we always abide by the principle of equality and mutual benefit, and are deeply trusted and recognized by customers.

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